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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Topological integration of RPPA proteomic data with multi-omics data for survival prediction in breast cancer via pathway activity inference

Fig. 4

Performance comparison between different methods and profiles. (a). In case of using a single omics profile. DRW(G) used RNA-Seq profile; DRW(M) used DNA methylation profile; DRW(P) used RPPA profile. (b). In case of using reduced RNA-Seq and DNA methylation profile. Each profile was reduced to include genes overlapping with RPPA proteins. iDRW(GRMR) used reduced RNA-Seq and reduced DNA methylation profile; iDRW(GRMRP) used reduced RNA-Seq, reduced DNA methylation, and RPPA profile; iDRWprop(GRMRP) performed network propagation using RWR on the proteome network. (c). Performance comparison of iDRW(GM) and iDRW(GMP). iDRW(GM) is a previous method which used RNA-seq and DNA methylation profile. iDRW(GMP) is our proposed model which used RNA-seq, DNA methylation, and RPPA profile in this study

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BMC Medical Genomics

ISSN: 1755-8794

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