Table 7 Meta-Analysis Results for Testing the Rare Variants Effects on Diastolic Blood Pressure
From: Meta-Qtest: meta-analysis of quadratic test for rare variants
Meta-Analysis | GENE | |||
|---|---|---|---|---|
Method | Test type | DTYMK (CHR 2) | CABIN1 (CHR 22) | PCCA (CHR 13) |
meta Q tests | Het-meta-Q1 | 8.87E-01 | 5.95E-01 | 1.59E-01 |
Het-meta-Q2 | 1.21E-06 | 8.67E-06 | 1.92E-04 | |
Het-meta-Q3 | 1.17E-06 | 6.91E-06 | 7.92E-05 | |
meta SKAT | Hom-meta-SKAT | 1.06E-01 | 3.93E-03 | 8.63E-06 |
Het-meta-SKAT | 1.43E-02 | 4.97E-03 | 8.11E-06 | |
Hom-meta-SKAT-O | 1.40E-01 | 7.74E-03- | 3.18E-06 | |
Het-meta-SKAT-O | 2.42E-02 | 1.03E-02 | 3.76E-06 | |
Other methods | Meta-burden | 1.51E-01 | 5.09E-01 | 4.78E-01 |
Fisher’s method (Q3) | NA | 1.65E-05 | 1.05E-04 | |
Score method (Q3) | NA | 1.50E-05 | 1.33E-02 | |