Table 1 Top five pathways from PHARAOH-GEE. The q-values after the multiple testing adjustment are presented in each cell, with their corresponding p-values within the brackets. The results of univariate PHARAOH are also provided on the right side of the table
Pathway | PHARAOH-GEE | GEEaSPU | Univariate PHARAOH | ||||
|---|---|---|---|---|---|---|---|
HDL | TG | FASTGLU | WAIST | BP | |||
Glyoxylate and dicarboxylate metabolism | 0.0929 (0.00063) | 0.16 (0.00099) | 0.987 (0.902) | 0.721 (0.021) | 0.772 (0.023) | 0.91 (0.842) | 0.916 (0.202) |
Glycosphingolipid biosynthesis ganglio series | 0.159 (0.0038) | 0.979 (0.804) | 0.987 (0.79) | 0.805 (0.658) | 0.855 (0.137) | 0.805 (0.359) | 0.695 (0.067) |
MAPK signaling pathway | 0.159 (0.00404) | 0.468 (0.126) | 0.987 (0.327) | 0.721 (0.234) | 0.855 (0.072) | 0.953 (0.901) | 0.997 (0.45) |
Valine-leucine and isoleucine biosynthesis | 0.159 (0.0043) | 0.979 (0.797) | 0.987 (0.242) | 0.871 (0.779) | 0.999 (0.801) | 0.91 (0.813) | 0.695 (0.067) |
Fatty acid metabolism | 0.436 (0.0173) | 0.977 (0.459) | 0.987 (0.834) | 0.721 (0.143) | 0.999 (0.893) | 0.903 (0.647) | 0.997 (0.909) |