Fig. 1

Identification of modules associated with gene expression of DD. a Dendrogram showing modules based on the dissimilarity of TOM (1-TOM). Color bars below show assignment of modules. b Heatmap showing the gene expression pattern of modules. Red and blue color lines indicate up- and down-regulation, respectively. c A Heatmap showing the results of the meta-analysis derived from one-color microarray dataset. Black indicates DEGs (FDR < 0.01). d A Heatmap showing results of DEGs analysis of two-color microarray dataset. Black color lines indicate DEGs (FDR < 0.01). e A Heatmap showing expression patterns of genes for red module. Black color lines indicate DEGs (FDR < 0.01). f A scatter plot of principal component analysis (PCA) showing a distinct separation of the expression level of red module genes between patients with DD and normal subjects