Fig. 2

Robustness of DD signature and its functional annotations. a Bar plots showing the results of module enrichment analysis using GSEA. Black dotted lines indicate significant threshold (FDR < 0.05). b Bar plots showing normalized enrichment score (NES) for results of module concentration analysis using GSEA. c ROC analysis with AUC showing the performance of classification using red module in (a). Randomly selected genes consist of the same number of the red module gene. d Bar plots showing the results of functional enrichment analysis. Red and orange color bars represent GO biological process and KEGG pathway, respectively. Black dotted lines indicate significant threshold (FDR < 0.05)