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Table 5 WPC Index

From: A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies

FS Method

NLSVR

PCR

NLSVR NSCLC-AD

p NSCLC-AD

NO FS

0.581

0.578

0.528

0.009

DEG

0.582

0.579

0.535

0.001

CTR1

0.581

0.576

0.519

0.056

CTR2

0.576

0.559

0.508

0.248

MRMR

0.579

0.575

NA

NA

BS

0.58

0.576

NA

NA

BC

0.575

0.571

NA

NA

Hist

0.552

0.552

NA

NA

Random Control

NA

0.498

NA

NA

  1. WPC Index for NLSVR and PCR models as well as values for non small cell lung cancer adenocarcinoma (NSCLC-AD) in select drugs. The-value for NSCLC-AD was calculated by 3000 random permutations of the test data to construct a null distribution. For example, there is a .01% chance of obtaining a higher WPC score randomly for NLSVR DEG models on NSCLC-AD. Note that a wpc score cannot be calculated for the random control for NLSVR due to a variance of 0 which results in division by 0 incalculated wpc scores