Fig. 2

Clustering analysis of the differentially methylated CpG sites. a: Venn diagram of the DMCpG sites in the pre-surgery patients as compared to the controls and in the post-surgery patients as compared to the controls. A total of 544 common sites were associated with obesity status, and 2678 DMCpG sites were related to an effect of bariatric surgery per se. b: Supervised clustering of the 544 CpGs that were differentially methylated in the pre-surgery patients as compared to the controls. c: Summary of the gene ontology (GO) analysis of the biological process categories for the 386 genes represented by the 544 differentially methylated CpG sites. d: Supervised clustering of the 2678 CpGs that were differentially methylated in the post-surgery patients as compared to the controls. e: Summary of the gene ontology (GO) analysis of the biological process categories for the 1638 genes represented by the 2678 differentially methylated CpG sites