Skip to main content

Table 3 Top 20 CpG sites that became differently methylated from control group after Roux-en Y gastric bypass

From: DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se

TargetID

Gene name

CHR

Gene region

Gene context

Methylation level normal weight

Methylation level Post-surgery

Δ

p

Hypomethylated CpG sites in obese women after RYGB

 cg07875360

NDUFS6;MRPL36

5

TSS200;TSS1500

Island

0.72 ± 0.03

0.40 ± 0.32

−0.31

0.0011

 cg01759136

 

6

  

0.68 ± 0.04

0.40 ± 0.30

−0.28

0.0034

 cg00554442

LMF1

16

TSS200

Island

0.26 ± 0.01

0.01 ± 0.01

−0.25

0.0046

 cg05444312

HIST1H2BM;HIST1H2AJ

6

TSS200;TSS200

S_Shore

0.40 ± 0.04

0.21 ± 0.19

−0.19

0.0009

 cg07962043

TMEM132A;TMEM132A

11

TSS1500;TSS1500

N_Shore

0.38 ± 0.02

0.25 ± 0.11

−0.13

<0.0001

 cg04450994

SLC22A23;SLC22A23

6

Body;Body

 

0.56 ± 0.06

0.45 ± 0.08

−0.11

0.0003

 cg01035945

ZNF323;ZNF323;ZKSCAN3

6

5’UTR;5’UTR;TSS1500

 

0.25 ± 0.03

0.14 ± 0.12

−0.11

0.0054

 cg07929642

ANKRD11

16

5’UTR

 

0.75 ± 0.05

0.64 ± 0.08

−0.11

0.0006

 cg06115576

DIP2C

10

Body

 

0.86 ± 0.02

0.75 ± 0.18

−0.11

<0.0001

 cg00510787

C6orf211;RMND1

6

TSS1500;5’UTR

N_Shore

0.29 ± 0.03

0.18 ± 0.13

−0.11

0.0097

Hypermethylated CpG sites in obese women after RYGB

 cg07275179

ATXN7;ATXN7

3

Body;Body

 

0.41 ± 0.09

0.53 ± 0.11

0.12

0.0002

 cg07212327

FAM49B

8

5’UTR

N_Shelf

0.50 ± 0.09

0.62 ± 0.10

0.12

<0.0001

 cg07401324

PTPRJ;PTPRJ

11

Body;Body

 

0.35 ± 0.07

0.48 ± 0.09

0.12

0.0002

 cg02353916

LOC285550

4

3’UTR

 

0.44 ± 0.10

0.57 ± 0.10

0.13

<0.0001

 cg00123214

RWDD3;RWDD3

1

Body;Body

S_Shelf

0.52 ± 0.23

0.65 ± 0.15

0.13

0.0058

 cg02387226

UNG;UNG

12

TSS1500;TSS1500

N_Shore

0.52 ± 0.02

0.65 ± 0.03

0.13

0.0069

 cg03494429

 

12

  

0.64 ± 0.07

0.79 ± 0.06

0.14

0.0093

 cg04412904

 

16

  

0.22 ± 0.19

0.37 ± 0.23

0.15

0.0028

 cg07093060

 

3

 

N_Shelf

0.66 ± 0.29

0.84 ± 0.10

0.18

0.0082

 cg07572984

 

14

  

0.60 ± 0.30

0.80 ± 0.20

0.20

0.0013

  1. Values showed in mean ± standard deviation; CHR: chromosome; Δ: variation between post-surgery patients and normal weight women; p: comparing post-surgery patients and normal weight women UTR: untranslated region; TSS: transcription start site; NDUFS6: NADH:ubiquinone oxidoreductase subunit S6; MRPL36: mitochondrial ribosomal protein L36; LMF1: lipase maturation factor 1; HIST1H2BM: histone cluster 1 H2B family member m; HIST1H2AJ: histone cluster 1 H2A family member j; TMEM132A: transmembrane protein 132A; SLC22A23: solute carrier family 22 member 23; ZNF323: zinc finger and SCAN domain containing 31; AN3: tripartite motif containing 44; ANKRD11: ankyrin repeat domain 11; DIP2C: disco interacting protein 2 homolog C; C6orf211: acidic residue methyltransferase 1; RMND1: required for meiotic nuclear division 1 homolog; ATXN7: ataxin 7; FAM49B: family with sequence similarity 49 member B; PTPRJ: protein tyrosine phosphatase, receptor type J; RWDD3: RWD domain containing 3; UNG: uracil DNA glycosylase
Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us