Skip to main content
Fig. 7 | BMC Medical Genomics

Fig. 7

From: Impact of cancer mutational signatures on transcription factor motifs in the human genome

Fig. 7

Inferred differential probability using exposure from the PCAWG dataset. a differential probability of creation minus disruption for all TF families with at least 10 members, across tumor subtypes containing at least 50 samples. The colored dots represent the samples of the different UMAP clusters, with size proportional to the number of these samples. b Mutational profile for the 3 signatures mostly represented within the melanoma (MELA) subtype. c Differential alteration probability (creation minus disruption) for all 30 signatures for the Ets-related family of motifs. UV-related signature 7 is highlighted in red

Back to article page