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Fig. 7 | BMC Medical Genomics

Fig. 7

From: Transcriptional consequences of impaired immune cell responses induced by cystic fibrosis plasma characterized via dual RNA sequencing

Fig. 7

Dysregulated canonical immune pathways and upstream regulators characterized CF and its phenotype. a & b Bar graphs represent canonical immune pathways significantly associated (p < 0.05) with dysregulated genes in the experimental gene expression dataset. a Seven canonical immune pathways indicated to be dysregulated in CF when compared to HC and their associated genes (b) Four canonical immune pathways indicated to be dysregulated in CF based on severe versus mild phenotypes. c & d Key upstream regulators predicted to be inhibited. Three upstream regulators were predicted to be inhibited in CF compared to HC based on their associated dysregulated molecules (c). Two upstream regulators inhibited in CF based on phenotype (d)

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