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Table 1 Demographic, clinical and genetic information for study cohort

From: Transcriptional consequences of impaired immune cell responses induced by cystic fibrosis plasma characterized via dual RNA sequencing

Comparison

Parameter

Group1

Group2

p-value

1

Condition

CF (n = 9)

Healthy controls (n = 3)

NA

Age in years, median (IQR)

7 (6, 18)

8 (8, 8)

NS

Gender: Male, n (%)

3 (33.3%)

1 (33.3%)

NS

2

CF Phenotype

Severe1 (n = 6)

Mild2 (n = 3)

NA

Age in years, median (IQR)

10 (7, 25)

6 (5, 7)

NS

Gender: Male, n (%)

3 (33.3%)

1 (33.3%)

NS

Gender: Male, n (%)

2 (33.3%)

1 (33.3%)

NS

Sweat chloride, median (IQR)

105 (100, 123)

67 (30, 77)

0.007*

Mucoid P. aeruginosa, n (%)

4 (66.7%)

0

NS

FEV1% predicted, median (IQR)

103 (85, 113)

113 (110, 118)

NS

F508del homozygotes, n (%)

6 (66.7%)

0

0.01†

  1. *T-test. †Fisher’s exact test. 1The severe group are homozygous for F508del (c.1521_1523delCTT), a class II CFTR variant associated with pancreatic insufficiency (PI) and more severe disease. 2The mild group were pancreatic sufficient and have a combination of F508del (c.1521_1523delCTT) and either S1251 N (c.3752G > A) and R117H;7 T (c.350G > A;1210 − 12 T [7]), and EX-19dup. The severity status was assigned as previously described [39,40,41,42]. NA not applicable. NS not significant