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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells

Fig. 2

Gene expression scales with chromosome copy number. a, Heatmap of the estimated copy number (ECN) of all chromosomes (columns) in single CB660 NSCs and GliNS2 CSCs (rows). On the scale, ECN = 0 indicates diploid gene expression levels. The column adjacent to the heatmap shows the cell cycle phase of each cell as determined in Fig. 1b with the color of the bar corresponding to the predicted cell cycle phase. b, Quantification of chromosomal instability in CB660 NSCs and GliNS2 CSCs. Bar, median; box 25th to 75th percentile; whiskers, minimum and maximum. P < 2E-16; Mann-Whitney U test comparing CB660 NSCs and GliNS2 CSCs. c and d, Heatmaps showing normalized gene expression in CB660 NSCs and GliNS2 CSCs for chromosome 7 (C) and chromosome 13 (D)

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