Fig. 1From: Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patientsCorrelation between gene expression, glucose and insulin homeostasis. Pearson correlation plots between log2 gene expression values of key lipogenic genes and HbA1c (a-c) or HOMA2-IR (d-f) are shown. Genes are fatty acid elongase-6 (ELOVL6), stearoyl-CoA desaturase (SCD) and fatty acid synthase (FASN). Liver samples from non-statin treated patients (n = 747) are indicated as blue dots, liver samples from statin-treated patients (n = 173) are indicated as red dots. The following correlation coefficients and P values were calculated for HbA1c: ELOVL6: r = 0.23, P = 7.2 × 10− 12; SCD: r = 0.24, P = 3.9 × 10− 13; FASN: r = 0.26, P = 3.3 × 10− 15. The following correlation coefficients and P values were calculated for HOMA2-IR: ELOVL6: r = 0.11, P = 2.9 × 10− 03; SCD: r = 0.11, P = 2.0 × 10− 03; FASN: r = 0.21, P = 1.6 × 10− 09. Abbreviations: HbA1c: hemoglobin A1c, HOMA2-IR: homeostasis model assessment of insulin resistanceBack to article page