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Table 5 Canonical Pathways identified by IPA software for 42 Housekeeping Genes Common to All Normalization Methods

From: Defining housekeeping genes suitable for RNA-seq analysis of the human allograft kidney biopsy tissue

Ingenuity Canonical Pathways

-log(p-value)

Ratio

Molecules

Pyrimidine Ribonucleotides Interconversion

2.58

0.0444

NME4,SMARCAL1

Pyrimidine Ribonucleotides De Novo Biosynthesis

2.55

0.0426

NME4,SMARCAL1

Salvage Pathways of Pyrimidine Ribonucleotides

1.95

0.0211

NME4,POMK

Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I

1.42

0.0435

NME4

Nucleotide Excision Repair Pathway

1.24

0.0286

POLR2B

Assembly of RNA Polymerase II Complex

1.09

0.02

POLR2B

Pyridoxal 5′-phosphate Salvage Pathway

0.983

0.0154

POMK

Mitotic Roles of Polo-Like Kinase

0.977

0.0152

ANAPC5

Protein Kinase A Signaling

0.836

0.005

PTPN14,ANAPC5

Androgen Signaling

0.767

0.00901

POLR2B

p38 MAPK Signaling

0.736

0.00833

MKNK1

RhoA Signaling

0.723

0.00806

RAPGEF6

Estrogen Receptor Signaling

0.711

0.00781

POLR2B

Hereditary Breast Cancer Signaling

0.665

0.00694

POLR2B

IL-12 Signaling and Production in Macrophages

0.66

0.00685

REL

Regulation of eIF4 and p70S6K Signaling

0.632

0.00637

MKNK1

CREB Signaling in Neurons

0.568

0.00538

POLR2B

RAR Activation

0.56

0.00526

REL

ERK/MAPK Signaling

0.541

0.005

MKNK1

Systemic Lupus Erythematosus Signaling

0.499

0.00444

SNRNP200

Huntington’s Disease Signaling

0.461

0.004

POLR2B

Protein Ubiquitination Pathway

0.441

0.00377

ANAPC5

Glucocorticoid Receptor Signaling

0.358

0.00295

POLR2B

Axonal Guidance Signaling

0.27

0.00221

MKNK1