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Table 2 Significant gene-trait associations (BioMe p < 0.1, STARNET p < 0.05) of genes known to be involved in lipid and glucose metabolism based on GO annotation

From: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

  Description GO BP annotation Trait p-value (BioMe) β (BioMe) p-value (STARNET) β (STARNET) Tissue (STARNET)
ACOT11 Acyl-CoA Thioesterase 11 GO:0006631 (fatty acid metabolic process) Glucose 0.059 40 0.040 −0.28 SKLM
ACSM3 Acyl-CoA Synthetase Medium-Chain Family Member 3 GO:0006631 (fatty acid metabolic process) LDL Cholesterol 0.060 −4.3 0.032 0.10 SKLM
ADCY4 Adenylate Cyclase 4 GO:007137 (cellular response to glucagon stimulus) Glucose 0.0095 39 0.025 −0.40 MAM
ADCY4 Adenylate Cyclase 4 GO:007137 (cellular response to glucagon stimulus) Hemoglobin A1c 0.034 1.4 0.034 −0.14 SF
AGMO Alkylglycerol Monooxygenase GO:0019432 (triglyceride biosynthetic process) Glucose 0.094 −16 0.021 0.33 AOR
APOC3 Apolipoprotein C3 GO:0006641 (triglyceride metabolic process) Triglycerides 0.0056 −56 0.0065 0.38 LIV
DGAT2 Diacylglycerol Acyltransferase 2 GO:0019432 (triglyceride biosynthetic process) Glucose 0.049 −19 0.024 0.56 LIV
DGAT2 Diacylglycerol Acyltransferase 2 GO:0019432 (triglyceride biosynthetic process) Cholesterol 0.078 −24 0.036 0.089 MAM
GAA Glucosidase Alpha, Acid GO:0006006 (glucose metabolic process) HDL Cholesterol 0.039 11 0.0021 −0.21 MAM
PCSK9 Proprotein Convertase Subtilisin/Kexin Type 9 GO:0008203 (cholesterol metabolic process) Glucose 0.042 −15 4.6E-05 0.65 LIV
PLCD4 Phospholipase C Delta 4 GO:0006629 (lipid metabolic process) Diastolic Blood Pressure 0.030 1.9 0.027 −2.6 MAM
  1. AOR aorta, MAM mammary artery, LIV liver, SF subcutaneous fat, SKLM skeletal muscle. β values represent effect size. Positive β in BioMe and negative β in STARNET indicate LoF and low gene expression are associated with increased trait measurements. Negative β in BioMe and positive β in STARNET indicate LoF and low gene expression are associated with decreased trait measurements