Table 2 Significant gene-trait associations (BioMe p < 0.1, STARNET p < 0.05) of genes known to be involved in lipid and glucose metabolism based on GO annotation
|  | Description | GO BP annotation | Trait | p-value (BioMe) | β (BioMe) | p-value (STARNET) | β (STARNET) | Tissue (STARNET) |
|---|---|---|---|---|---|---|---|---|
ACOT11 | Acyl-CoA Thioesterase 11 | GO:0006631 (fatty acid metabolic process) | Glucose | 0.059 | 40 | 0.040 | −0.28 | SKLM |
ACSM3 | Acyl-CoA Synthetase Medium-Chain Family Member 3 | GO:0006631 (fatty acid metabolic process) | LDL Cholesterol | 0.060 | −4.3 | 0.032 | 0.10 | SKLM |
ADCY4 | Adenylate Cyclase 4 | GO:007137 (cellular response to glucagon stimulus) | Glucose | 0.0095 | 39 | 0.025 | −0.40 | MAM |
ADCY4 | Adenylate Cyclase 4 | GO:007137 (cellular response to glucagon stimulus) | Hemoglobin A1c | 0.034 | 1.4 | 0.034 | −0.14 | SF |
AGMO | Alkylglycerol Monooxygenase | GO:0019432 (triglyceride biosynthetic process) | Glucose | 0.094 | −16 | 0.021 | 0.33 | AOR |
APOC3 | Apolipoprotein C3 | GO:0006641 (triglyceride metabolic process) | Triglycerides | 0.0056 | −56 | 0.0065 | 0.38 | LIV |
DGAT2 | Diacylglycerol Acyltransferase 2 | GO:0019432 (triglyceride biosynthetic process) | Glucose | 0.049 | −19 | 0.024 | 0.56 | LIV |
DGAT2 | Diacylglycerol Acyltransferase 2 | GO:0019432 (triglyceride biosynthetic process) | Cholesterol | 0.078 | −24 | 0.036 | 0.089 | MAM |
GAA | Glucosidase Alpha, Acid | GO:0006006 (glucose metabolic process) | HDL Cholesterol | 0.039 | 11 | 0.0021 | −0.21 | MAM |
PCSK9 | Proprotein Convertase Subtilisin/Kexin Type 9 | GO:0008203 (cholesterol metabolic process) | Glucose | 0.042 | −15 | 4.6E-05 | 0.65 | LIV |
PLCD4 | Phospholipase C Delta 4 | GO:0006629 (lipid metabolic process) | Diastolic Blood Pressure | 0.030 | 1.9 | 0.027 | −2.6 | MAM |