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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes

Fig. 1

Somatic mutations affecting components of the MHC-I molecule. a The total number of nonsynonymous mutations targeting the genes encoding the components of the MHC-I complex, B2M and HLA-A, HLA-B or HLA-C proteins, across all TCGA patients. The HLA mutation counts were obtained via Polysolver. b Schematic representation of the effects of mutations that alter the cell surface composition of MHC-I. An HLA mutation will affect a specific MHC-I molecule, whereas a B2M mutation will affect all MHC-I molecules; both mutations can increase the mutation burden of the patient. In the case of an HLA mutation, the patient mutation burden should include more neoantigens with affinity for the mutated HLA allele. The MHC-I molecule displayed is composed of B2M (pink) and HLA-A (blue) proteins (PDB: 3bo8)

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