Fig. 3

Increased mutational burden is related to mutations in MHC-I. a and c Boxplots showing the total number of expressed nonsynonymous mutations of TCGA patients who acquired a mutation in their B2M protein or in one of their HLA alleles versus patients who did not acquire any B2M or HLA mutation, (a) for all patients, and (c) for only MSS patients. Sample sizes for each patient group are written under their name. b and d Boxplots showing total number of expressed nonsynonymous mutations for TCGA patients with or without B2M or HLA mutations, (b) for all patients, and (d) for only MSS patients. Patients are divided by tumor type and only the tumor types with at least 5 mutated patients are shown. P-values are adjusted for multiple comparisons using the Benjamini–Hochberg procedure. Sample sizes for each patient group are written under the tissue name