Fig. 2

a) 9 signatures (including background) discovered by applying SparseSignatures to the whole genomes of 555 breast tumors. For signatures 1–5, the corresponding COSMIC signature is listed in red along with its cosine similarity to the discovered signature. b) Boxplots showing the number of mutations attributed to each signature in different classes of breast tumors. c) Boxplots showing the fraction of mutations attributed to each signature in each sample, for different classes of breast tumors. d) Average beta-value (representing the extent of cytosine methylation) of CpG sites, in different classes of breast tumors, based on data from TCGA [22]