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Table 1 11 protein-coding genes show enrichment for indels/structural variant breakpoints in BRCA1/2-mutated tumors

From: Comprehensive genomic characterization of breast tumors with BRCA1 and BRCA2 mutations

  Gene Chromosome Length (bp) Number of indels/SV breakpoints Adjusted p-value Adjusted p-value (corrected for copy number) Adjusted p-value (corrected for copy number) BRCA1 only Adjusted p-value (corrected for copy number) BRCA2 only
1 RB1 13 176,159 17 1.31 × 10−9 1.69 × 10− 10 4.60 × 10− 9 1.00
2 TP53 17 6986 5 5.48 × 10− 5 2.13 × 10− 5 6.17 × 10− 4 1.00
3 PTEN 10 101,523 10 1.45 × 10−4 7.53 × 10−5 1.66 × 10−2 1.00
4 ETV6 12 240,919 13 0.00102 0.00243 4.17 × 10−5 1.00
5 RUNX1 21 256,765 13 0.00210 0.00275 4.73 × 10−5 1.00
6 KLHL8 4 32,021 6 0.00372 0.00293 3.73 × 10−4 1.00
7 P4HB 17 16,460 5 0.00380 0.00592 5.62 × 10−2 1.00
8 NME7 1 234,926 12 0.00581 0.0695 1.83 × 10−3 1.00
9 EFNA5 5 289,359 13 0.0080 0.00193 3.28 × 10−5 1.00
10 ARGLU1 13 23,924 5 0.0233 0.0234 4.17 × 10−3 1.00
11 DHX32 10 44,138 6 0.0236 0.0168 1.00 1.00