Table 1 KEGG pathways enriched with a significant number of genes involved in CP

Pathways in cancer

DVL3;ERBB2;FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;GSTP1;ARNT;LEF1;PDGFRA;PTCH1;RARA;BMP2;BMP4;TGFA;TGFB1;TGFB3;WNT5A;WNT11;WNT10A;AXIN2;FGF18;WNT3A;FGF19;CDH1

Breast cancer

DVL3;ERBB2;FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;JAG2;LEF1;WNT5A;WNT11;WNT10A;AXIN2;FGF18;WNT3A;FGF19

Melanoma

FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;PDGFRA;FGF18;FGF19;CDH1

Hippo signaling pathway

DVL3;FGF1;GDF6;LEF1;BMP2;BMP4;BMP7;TGFB1;TGFB3;WNT5A;WNT11;WNT10A;AXIN2;WNT3A;CDH1

Basal cell carcinoma

DVL3;LEF1;PTCH1;BMP2;BMP4;WNT5A;WNT11;WNT10A;AXIN2;WNT3A

Signaling pathways regulating pluripotency of stem cells

DVL3;FGF2;FGFR1;FGFR3;FGFR2;JARID2;PAX6;BMP2;BMP4;WNT5A;WNT11;WNT10A;AXIN2;WNT3A

Rap1 signaling pathway

FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;PDGFRA;FGF18;FGF19;CDH1

Regulation of actin cytoskeleton

FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;MYH9;PDGFRA;FGF18;FGF19

MAPK signaling pathway

FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;PDGFRA;TGFB1;TGFB3;FGF18;FGF19

Ras signaling pathway

FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;TBK1;PDGFRA;FGF18;FGF19

Chemical carcinogenesis

NAT2;ADH1C;CYP1A1;CYP1B1;GSTP1;GSTT1;ARNT;UGT1A7;NAT1

One carbon pool by folate

ALDH1L1;DHFR;MTHFD1;MTHFR;MTR

PI3K-Akt signaling pathway

COL2A1;FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;NOS3;PDGFRA;FGF18;FGF19

TGF-beta signaling pathway

GDF6;BMP2;BMP4;BMP7;TGFB1;TGFB3;NOG

Prostate cancer

ERBB2;FGFR1;FGFR2;GSTP1;LEF1;PDGFRA;TGFA

Cysteine and methionine metabolism

AHCYL2;BHMT2;MTR;BHMT;CBS

Proteoglycans in cancer

ERBB2;FGF2;FGFR1;PTCH1;SDC2;TGFB1;WNT5A;WNT11;WNT10A;WNT3A

Metabolism of xenobiotics by cytochrome P450

ADH1C;CYP1A1;CYP1B1;GSTP1;GSTT1;UGT1A7

Adherens junction

ERBB2;FGFR1;LEF1;NECTIN1;NECTIN2;CDH1

EGFR tyrosine kinase inhibitor resistance

ERBB2;FGF2;FGFR3;FGFR2;PDGFRA;TGFA

MicroRNAs in cancer

CYP1B1;ERBB2;FGFR3;PDGFRA;ABCB1;TPM1;TP63;WNT3A

Caffeine metabolism

NAT2;NAT1

Tryptophan metabolism

TPH2;CYP1A1;CYP1B1;DDC

Central carbon metabolism in cancer

ERBB2;FGFR1;FGFR3;FGFR2;PDGFRA

Melanogenesis

DVL3;LEF1;WNT5A;WNT11;WNT10A;WNT3A

Arginine biosynthesis

ASL;ASS1;NOS3

Wnt signaling pathway

DVL3;LEF1;WNT5A;WNT11;WNT10A;AXIN2;WNT3A

Biosynthesis of amino acids

ASL;ASS1;MTR;PAH;CBS