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Table 1 Clinical and pathological features of MTC positive and negative for RET p.G548V mutation

From: Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma

 

MTC (n = 37)

p.G548 V Negative (n = 26)

p.G548 V Positive (n = 11)

P-value

Gender

 Male

20

12/26 (46%)

8/11 (73%)

0.1691

 Female

17

14/26 (54%)

3/11 (27%)

 

Sporadic

14

9/26 (35%)

5/11 (45%)

0.7130

Familial

23

17/26 (65%)

6/11 (55%)

 MEN 2A

21

15/17 (88%)

6/6 (100%)

1.000

 MEN 2B

2

2/17 (12%)

0/6 (0%)

1.000

Homozygosis

5

5/11 (45%)

Heterozygosis

6

6/11 (55%)

Age of Diagnostics (mean ± SD)

 

38.17 ± 14.28

45.82 ± 18.61

0.1903

Metastasis

 Yes

19

15/26 (57,7%)

4/11 (36,4%)

0.2252

 No

11

6/26 (23%)

5/11 (45,5%)

RET mutations

 Negative

11

8/26 (30%)

3/11 (28%)

1.000

 Positivea

26

18/26 (70%)

8/11 (72%)

 p.G533C

9

6/18 (33%)

3/8 (38%)

1.000

 p.C634_

6

4/18 (27%)

1/8 (12%)

0.6279

 p.C634Y/Y791F

7

5/18 (28%)

2/8 (25%)

1.000

 p.M918 T

4

2/18 (12%)

2/8 (25%)

0.5633

  1. aSomatic (n = 3) and Germline (n = 23). For details, see supplementary Table 1