From: Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma
MTC (n = 37) | p.G548 V Negative (n = 26) | p.G548 V Positive (n = 11) | P-value | |
---|---|---|---|---|
Gender | ||||
Male | 20 | 12/26 (46%) | 8/11 (73%) | 0.1691 |
Female | 17 | 14/26 (54%) | 3/11 (27%) | |
Sporadic | 14 | 9/26 (35%) | 5/11 (45%) | 0.7130 |
Familial | 23 | 17/26 (65%) | 6/11 (55%) | |
MEN 2A | 21 | 15/17 (88%) | 6/6 (100%) | 1.000 |
MEN 2B | 2 | 2/17 (12%) | 0/6 (0%) | 1.000 |
Homozygosis | 5 | – | 5/11 (45%) | – |
Heterozygosis | 6 | – | 6/11 (55%) | |
Age of Diagnostics (mean ± SD) | 38.17 ± 14.28 | 45.82 ± 18.61 | 0.1903 | |
Metastasis | ||||
Yes | 19 | 15/26 (57,7%) | 4/11 (36,4%) | 0.2252 |
No | 11 | 6/26 (23%) | 5/11 (45,5%) | |
RET mutations | ||||
Negative | 11 | 8/26 (30%) | 3/11 (28%) | 1.000 |
Positivea | 26 | 18/26 (70%) | 8/11 (72%) | |
p.G533C | 9 | 6/18 (33%) | 3/8 (38%) | 1.000 |
p.C634_ | 6 | 4/18 (27%) | 1/8 (12%) | 0.6279 |
p.C634Y/Y791F | 7 | 5/18 (28%) | 2/8 (25%) | 1.000 |
p.M918 T | 4 | 2/18 (12%) | 2/8 (25%) | 0.5633 |