Fig. 10

Summary of key biological processes and pathways affected by genes underlying refractive eye development and found to be linked to myopia in UK Biobank and CREAM human cohorts. a Hierarchical clustering diagram showing top 30 biological processes affected by genes underlying baseline refractive eye development in humans. Outer circle shows hierarchical clusters of biological processes (identified by different colors) linked to baseline refractive development; inner circle shows clusters of the corresponding genes up- or down-regulated in myopic mice versus hyperopic mice. b Top twenty-five canonical pathways affected by the genes underlying baseline refractive eye development in humans. Horizontal yellow line indicates P = 0.05. Z-score shows activation or suppression of the corresponding pathways