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Fig. 11 | BMC Medical Genomics

Fig. 11

From: Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia

Fig. 11

Summary of key biological processes and pathways affected by genes regulating susceptibility to myopia and found to be linked to myopia in UK Biobank and CREAM human cohorts. a Hierarchical clustering diagram showing top 30 biological processes affected by genes regulating susceptibility to myopia in humans. Outer circle shows hierarchical clusters of biological processes (identified by different colors) underlying regulation of susceptibility to myopia; inner circle shows clusters of the corresponding genes up- or down-regulated in mice with high susceptibility to myopia versus mice with low susceptibility to myopia. b Top twenty-five canonical pathways affected by the genes regulating susceptibility to myopia in humans. Horizontal yellow line indicates P = 0.05. Z-score shows activation or suppression of the corresponding pathways

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