Table 1 Evolutionary conservation of retinal signaling pathways involved in refractive eye development

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4-hydroxyproline degradation I

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Actin cytoskeleton signaling

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Aldosterone signaling in epithelial cells

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Amyloid processing

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Amyotrophic lateral sclerosis signaling

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Androgen receptor signaling

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Antiproliferative role of somatostatin receptor 2 signaling

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Calcium signaling

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Choline biosynthesis III

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Chondroitin sulfate biosynthesis

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Circadian rhythm signaling

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Clathrin-mediated endocytosis signaling

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CREB signaling in neurons

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CXCR4 signaling

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Diphthamide biosynthesis

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Dopamine receptor signaling

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Dopamine-DARPP32 feedback signaling

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EIF2 signaling

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eNOS signaling

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Ephrin B signaling

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Ephrin receptor signaling

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Epithelial adherens junction signaling

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ERK/MAPK signaling

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Estrogen receptor signaling

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GABA receptor signaling

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Gap junction signaling

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Glucocorticoid receptor signaling

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Glutamate degradation/Glutamate receptor signaling

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Glutathione biosynthesis

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Glutathione redox reactions I

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Glutathione-mediated detoxification

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Glycoaminoglycan-protein linkage region biosynthesis

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Gαq signaling

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HIPPO signaling

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HMGB1 signaling

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Huntington’s disease signaling

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IGF-1 signaling

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ILK signaling

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Insulin receptor signaling

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Integrin signaling

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L-cysteine degradation I

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L-cysteine degradation III

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Mismatch repair in eukaryotes

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mTOR signaling

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NF-κB signaling

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nNOS signaling

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NRF2-mediated oxidative stress response

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Oncostatin M signaling

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Phospholipase C signaling

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Phototransduction pathway

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PI3K/AKT signaling

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PPAR signaling

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PPARα/RXRα activation

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Production of nitric oxide and reactive oxygen species

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Protein kinase A signaling

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Protein ubiquitination pathway

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PTEN signaling

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Purine nucleotides de novo biosynthesis II

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Purine nucleotides degradation II (aerobic)

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RAN signaling

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RAR activation

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Regulation of eIF4 and p70S6K signaling

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Regulation of the epithelial-mesenchymal transition pathway

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Relaxin signaling

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RhoGDI signaling

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Semaphorin signaling in neurons

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Signaling by Rho family GTPases

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Sumoylation pathway

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Synaptic long-term depression

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Synaptic long-term potentiation

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TGF-β signaling

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Tight junction signaling

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tRNA splicing

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Wnt/Ca + pathway

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Xenobiotic metabolism signaling

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α-adrenergic signaling

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β-adrenergic signaling