Skip to main content
Fig. 2 | BMC Medical Genomics

Fig. 2

From: Directional association test reveals high-quality putative cancer driver biomarkers including noncoding RNAs

Fig. 2

Non-monotonic directional interaction patterns from two known cancer genes to the cancer status of human samples. The horizontal axes are log-scaled abundance of the most expressed TSS of each gene from FANTOM5. The vertical axes of the two top plots represent tissue types. ‘Cancer’ indicates a sample is from a cancer cell-line, ‘Normal’ for a sample from a non-cancer tissue. The vertical axes of the two bottom plots are the probability density of gene expression level. FunChisq reported high statistical significance of both genes’ directional association with cancer suggested by the low p-values, while t-test returned insignificant results indicated by large p-values. ap1@KAT6A, the most transcribed TSS of known cancer gene KAT6A, is either up- or down-regulated in 527 non-cancer samples of various tissues, but has an intermediate level of expression in 225 samples of various cancers. bp1@BRAF, the most transcribed TSS of known cancer gene BRAF, has a similar non-monotonic expression profile directionally associated with cancer status

Back to article page