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Table 1 Comparison of widely used biomarker detection methods

From: Directional association test reveals high-quality putative cancer driver biomarkers including noncoding RNAs

MethodsAdvantagesDisadvantages
Pearson’s chi-squared testModel freeNo directionality
t-testNo discretizationNo non-monotonicity
Wilcoxon testNonparametricNo non-monotonicity
Logistic regressionNonlinear No discretizationRequires a parametric model
DESeq2; edgeRGeneralized linear modelRequires a parametric model