Table 1 Comparison of widely used biomarker detection methods
Methods | Advantages | Disadvantages |
|---|---|---|
Pearson’s chi-squared test | Model free | No directionality |
t-test | No discretization | No non-monotonicity |
Wilcoxon test | Nonparametric | No non-monotonicity |
Logistic regression | Nonlinear No discretization | Requires a parametric model |
DESeq2; edgeR | Generalized linear model | Requires a parametric model |