Table 3 Enrichment by function of gene sets derived from significant FC and from Hamming distance d ≤ 1 neighborhoods of the network-based predictor genes ID3, MBTPS1, NOG, SFXN2, BMX, SLCA11 in the stroke networks. The last column shows the number of genes in the cluster, the associated enrichment odds ratio, the raw/Benjamini-Hochberg FDR-adjusted p-value for the OR are p/p*

Genes with significantly different centrality values between stroke and control networks

nucleoplasm

34, 2.18, 0.005/0.344

ID3 d ≤ 1 neighbors in stroke network

Negative regulation of apoptotic process in bone marrow

2, 1049.5, 0.002/0.198

Transcription factor binding

3839.6, 0.006/0.274

Cytoplasm

6, 22.29, 0.024/0.394

MBTPS1 d ≤ 1 neighbors in stroke network

Zinc finger

3,89.23,4.8 × 10⁻⁴/0.077

Ligase

5,5.60,0.011/0.978

Transmembrane helix

23,1.581,0.014,0.427

Lumenal topological domain

5, 4.21,0.029/0.909

NOG d ≤ 1 neighbors in stroke network

Transmembrane transport

3,39.57,0.002/0.727

Endoplasmic reticulum lumen

5,6.98,0.005,0.437

Regulation of microvillus assembly

2, 100.25, 0.020/0.994

Arachinodic acid metabolism

3,11.94,0.024/0.795

Poly(A) RNA binding

10,2.27,0.028/0.991

SFXN2 d ≤ 1 neighbors in stroke network

Phosphoprotein

39, 1.52, 0.001/0.124

Mitochondrial

13,2.83,0.002/0.156

Acetylation

19,1.78,0.002/0.136

BMX d ≤ 1 neighbors in stroke network

Nucleotide-binding

14,2.60,0.002/0.257

Nuclear localization signal

6,5.64,0.004/0.664

ATP-binding

11,2.63,0.004/0.664

Phosphoprotein

SLC22A1 d ≤ 1 neighbors in stroke network

Mitochondrion

11,3.07,0.003/0.344

Protein binding

42,1.28,0.017/0.929

Nucleolus

8,2.74,0.024/0.914

DNA catabolic process

2,66.63,0.020/1.0

ATP-binding

10, 2.24,0.030,0.815