Fig. 3

Deconvolution of skin biopsies from healthy subjects and patients with psoriasis and atopic dermatitis. a Comparison of the average cellular abundance derived from gene expression data of 648 biopsy samples from the skin of healthy subjects and patients with atopic dermatitis and psoriasis. The samples from psoriasis and atopic dermatitis account for lesional and non-lesional skin. The average cellular abundance is combined into five groups, i.e. immune cells (turquoise), stem cells (brown), keratinocytes (light brown), adipocytes (light yellow), and others (white). b Detailed description of average values in the fractions of immune infiltrates across healthy and disease skin phenotypes (depicted in the donut chart from panel a). c Heatmap of significant over (red) or under (blue) represented cell types comparing lesional to non-lesional and healthy skin samples. Non-significant results (uncorrected p > 0.05) are kept blank. Significant results after correction for multiple testing are labeled with a star. d-e Comparison of the estimated cell-type specific fractions for mild (x-axis) and severe (y-axis) cases of psoriasis and atopic dermatitis. The diagonal in each plot indicates the point at which the estimated fraction for a given cell type for the mild case would be equal to the one of the severe cases. The deviation from the diagonal indicates the difference between mild and severe cases of psoriasis and atopic dermatitis. Cell types with a corrected p-value lower than 0.05 are indicated with an asterisk