Table 2 Summary of GWAS results and associations with IgAN in two selected SNPs
From: Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
Gene symbol | SNP | Type | Control | IgAN | Model | OR (95% CI) | p-value | |
|---|---|---|---|---|---|---|---|---|
location/ | n (%) | n (%) | ||||||
Allele | A | 563 (62.0) | 181 (50.0) | 1 | ||||
LOC105373592 | G | 339 (38.0) | 181 (50.0) | 1.66 (1.30–2.12) | 5.00E-05 | |||
Intron | rs10172700 | A/A | 184 (40.8) | 50 (27.6) | Log-additive | 1.59 (1.26–2.02) | 0.0001 | |
Genotype | A/G | 195 (43.2) | 81 (44.8) | Dominant | 1.81 (1.24–2.63) | 0.0017 | ||
G/G | 72 (16.0) | 50 (27.6) | Recessive | 2.01 (1.33–3.03) | 0.0011 | |||
Allele | G | 850 (93.0) | 311 (86.0) | 1 | ||||
ANKRD16 | C | 60 (7.0) | 51 (14.0) | 2.32 (1.57–3.45) | 1.92E-05 | |||
Exon (missense) | rs2296136 | G/G | 396 (87.0) | 133 (73.5) | Log-additive | 2.39 (1.59–3.59) | < 0.0001 | |
Genotype | G/C | 58 (12.8) | 45 (24.9) | Dominant | 2.42 (1.58–3.72) | 0.0001 | ||
C/C | 1 (0.2) | 3 (1.7) | Recessive | 7.65 (0.79–74.05) | 0.053 |