Table 3 Association results of the two validated SNPs from GWAS in the replication cohort
From: Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans
Gene symbol location/ | SNP | Genotype | Control | IgAN | Model | OR (95% CI) | p-value | Combined p-value (GWAS + replication) |
|---|---|---|---|---|---|---|---|---|
n (%) | n (%) | |||||||
LOC105373592 | rs10172700 | A/A | 187 (42.7) | 109 (35.2) | Log-additive | 1.15 (0.94–1.41) | 0.18 | 0.16 |
Intron | A/G | 177 (40.4) | 150 (48.4) | Dominant | 1.37 (1.02–1.86) | 0.03 | 0.04 | |
G/G | 74 (16.9) | 51 (16.4) | Recessive | 0.97 (0.66–1.43) | 0.87 | 0.99 | ||
ANKRD16 Exon (missense) | rs2296136 | G/G | 373 (85.2) | 244 (78.7) | Log-additive | 1.40 (0.99–1.98) | 0.05 | 0.0045 |
G/C | 59 (13.5) | 63 (20.3) | Dominant | 1.55 (1.06–2.27) | 0.02 | 0.0027 | ||
C/C | 6 (1.4) | 3 (1.0) | Recessive | 0.70 (0.17–2.84) | 0.62 | 0.76 |