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Fig. 8 | BMC Medical Genomics

Fig. 8

From: Transcriptome analysis of human monocytic cells infected with Burkholderia species and exploration of pentraxin-3 as part of the innate immune response against the organisms

Fig. 8

The impact of PTX3 on bacterial phagocytosis and replication within human monocytes. Pre-infection heterocomplexes of 10 μg/mL of PTX3 and 107 Bt were used to infect 1 × 106 human monocytes in the absence of complement. Intracellular bacterial CFUs were enumerated 4 h postinfection (phagocytosis) and 10 h postinfection (replication). PTX3-bound or unbound Bt did not exhibit significant differences in phagocytic uptake or replication within human MM6 monocytes (unpaired t-test). Both PTX3 pre-bound and unbound Bt displayed significant intracellular growth within human MM6 monocytes (**p = 0.0026, unpaired t-test)

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