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Table 2 Associations between isoform expression levels of APOBEC3A and APOBEC3B and germline APOBEC3A/B deletion

From: Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types

Cancer typea

uc003awn

uc011aoc

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Beta

P

Beta

P

Beta

P

bladder

1.52

4.5 × 10− 4

−1.31

2.9 × 10−7

3.42

2.2 × 10− 39

breast

0.92

5.1 × 10− 4

− 0.71

3.0 × 10− 8

3.03

6.9 × 10− 66

cervical

1.44

0.06

−2.79

2.6 × 10− 10

2.67

5.5 × 10− 11

lungb

0.28

0.52

−1.35

2.6 × 10− 13

2.33

2.1 × 10− 12

lungc

0.55

0.51

− 3.60

9.1 × 10− 16

1.08

0.02

head and neck

0.86

0.06

−5.74

3.8 × 10− 65

2.63

6.3 × 10− 17

stomach

1.05

0.23

−0.25

0.37

3.01

8.0 × 10− 6

pancreas

−0.14

0.91

−1.00

0.11

0.95

0.14

thyroid

0.90

4.5 × 10−3

−0.38

9.2 × 10−5

2.13

2.2 × 10−22

kidney

0.43

0.37

0.02

0.87

2.26

1.0 × 10−8

  1. “a” Sample size for each cancer type: bladder (N = 286), breast (N = 734), cervical (N = 133), lung adenocarcinoma (N = 363), lung squamous carcinoma (N = 85), head and neck (N = 323), stomach (N = 66), pancreas (N = 90), thyroid (N = 333), kidney (N = 143). “b” and “c” refers to lung adenocarcinoma and lung squamous carcinoma, respectively. A univariate regression analysis was constructed to include APOBEC-mutational signature as dependent variables and expression levels as the independent variable for each isoform of each cancer type. The significance level at P = 0.005, corresponding to a threshold with a Bonferroni-correction of P = 0.05, given 10 tests
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BMC Medical Genomics

ISSN: 1755-8794

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