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Fig. 6 | BMC Medical Genomics

Fig. 6

From: The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

Fig. 6

a Enriched gene sets related to the Neuron System. The first four columns plot Normalized Enrichment Score (NES) of GSEA analyses from (1), (2), (4), and (3) vs (5), respectively, where red and blue correspond to positive and negative NES scores, respectively. The fifth column indicates the Agreement Class of each gene set, assigned according to HD+ CAU-specificity. Cells with white dots indicate that gene set is significantly enriched in the corresponding analysis. b Overlap of significantly enriched gene sets regardless of category. The gene sets enriched in (4) are a subset of those in (1), and thus are not listed. c Distribution of gene sets by agreement class divided into ten high level functional categories, showing that some functions are more selectively enriched in HD+ CAU relative to BA9 than others. d Graph-based representation of the Cell Cycle/Development gene sets from C. Each node is a gene set, and nodes with connected edges share more than 25% of their leading edge genes, thus representing the same expression signal

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