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Table 6 Unique response genes in HD+ CAU, corresponds to only the green area diagram in Fig. 2b

From: The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

Symbol

Gene name

(1) BM

(1) L2FC

(2) BM

(2) L2FC

(4) BM

(4) L2FC

CDHR4

Cadherin Related Family Member 4

3.93

-0.92

16.52

-1.0

47.49

-4.6

SIK1

Salt Inducible Kinase 1

172.19

0.96

351.77

2.86

452.63

3.11

CH507-9B2.1

Uncharacterized ncRNA gene

202.22

-0.98

172.02

2.0

292.54

5.39

TMIE

Transmembrane Inner Ear

286.83

-0.21

387.23

0.07

380.24

2.33

DHFRP1

Dihydrofolate Reductase Pseudogene1

ND

ND

ND

ND

21.19

7.87

RPS10-NUDT3

Read-through transcript

247.15

0.29

297.06

0.59

386.09

2.01

RSC1A1

Regulator Of Solute Carriers 1

ND

ND

24.01

4.78

41.98

5.89

CCL19

C-C Motif Chemokine Ligand 19

34.45

-0.21

13.66

-2.58

166.21

-4.54

LRRC71

Leucine Rich Repeat Containing 71

11.97

0.61

33.61

0.13

67.87

-3.71

HSPH1

Heat Shock Protein Family H Member 1

9773.91

0.25

13966.0

0.6

20222.49

1.72

CX3CR1

C-X3-C Motif Chemokine Receptor 1

338.16

0.08

389.08

-0.81

472.45

-2.87

UBE2F-SCLY

Read-through transcript

31.89

-0.18

45.88

0.83

48.19

4.65

NSFP1

N-Ethylmaleimide-Sensitive Factor Pseudogene 1

15.47

-1.69

51.57

-0.15

23.53

8.09

RPL17-C18orf32

Read-through transcript

275.3

-0.13

417.4

-0.36

523.12

2.23

THBS1

Thrombospondin 1

205.54

0.45

347.57

2.02

1448.89

2.64

DYDC2

DPY30 Domain Containing 2

51.37

-0.74

154.16

-1.57

251.82

-2.49

CBSL

Cystathione-Beta-Synthase Like

754.57

0.3

746.02

2.38

789.33

3.06

PTGS2

Prostaglandin-Endoperoxide Synthase 2

313.94

0.01

390.51

1.64

291.52

2.1

LINC00473

Long Intergenic Non-Protein Coding RNA 473

60.5

0.41

68.35

1.52

75.01

3.55

CCDC33

Coiled-Coil Domain Containing 33

9.19

-1.08

37.91

-1.46

60.08

-5.15

SLC38A5

Solute Carrier Family 38 Member 5

505.13

-0.12

530.55

-0.83

641.39

-2.4

NPIPB15

Nuclear Pore Complex Interacting Protein Family Member B15

177.05

0.61

112.27

-3.21

231.41

-3.9

NPIPA8

Nuclear Pore Complex Interacting Protein Family Member A8

345.69

0.52

256.3

-1.61

82.36

-6.91

LTF

Lactotransferrin

45.19

-0.52

152.43

-0.91

1448.49

3.24

RPL10P9

Ribosomal Protein L10 Pseudogene 9

29.12

0.64

76.79

2.08

107.51

6.1

RP5-850E9.3

Read-through transcript

106.96

-0.13

175.87

0.45

78.98

4.96

  1. Base mean columns are the mean normalized counts from the corresponding analysis. L2FC is log 2 fold change estimated by DESeq2. FDR <0.05 are considered significant for analyses (1) and (2). BM - base mean (number of normalized counts) for the gene. ND - genes not detected or too lowly abundant for consideration in the corresponding samples