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Table 7 Significantly enriched pathways in intersection of (1) and (4) or unique to (2) from Fig. 4

From: The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

Pathway (1) NES (2) NES (4) NES
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 1.76 2.56 2.29
PID SMAD2 3NUCLEAR PATHWAY 1.91 2.24 1.85
PID P53 DOWNSTREAM PATHWAY 1.86 2.26 1.84
PID AP1 PATHWAY 1.8 2.1 2.03
REACTOME HEMOSTASIS 1.46 1.87 1.46
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 1.52 2.56 1.76
REACTOME INNATE IMMUNE SYSTEM 1.52 2.16 1.4
BIOCARTA CK1 PATHWAY NS -1.88 NS
REACTOME INSULIN SYNTHESIS AND PROCESSING NS -1.85 NS
PID REG GR PATHWAY NS 1.56 NS
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE NS -1.75 NS
REACTOME NEUROTRANSMITTER RELEASE CYCLE NS -1.7 NS
KEGG ARACHIDONIC ACID METABOLISM NS 1.58 NS
PID HNF3A PATHWAY NS 1.61 NS
REACTOME POTASSIUM CHANNELS -1.78 NS -1.74
BIOCARTA NFAT PATHWAY 1.95 NS 1.87
  1. NES = normalized enrichment score from GSEA, where positive or negative values indicate the genes in the pathway are increased or decreased, respectively, in disease compared with control. NS = not significant