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Table 9 Top 10 genes that show different effect sizes (L2FC) between (3) and (5)

From: The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

ENSGID

Gene symbol

HD+ L2FC (3)

GTEx L2FC (5)

Δ (3) vs (5) L2FC

t

ENSG00000160401

CFAP157

-0.13

4.30

-4.43

20.45

ENSG00000077327

SPAG6

-2.20

2.64

-4.84

15.28

ENSG00000152611

CAPSL

-2.59

3.65

-6.24

14.63

ENSG00000181085

MAPK15

-1.65

2.71

-4.36

12.89

ENSG00000154914

USP43

-3.32

-0.80

-2.52

12.87

ENSG00000169436

COL22A1

-3.82

-0.31

-3.51

12.82

ENSG00000259024

TVP23C-CDRT4

2.55

-0.02

2.57

-12.75

ENSG00000162747

FCGR3B

3.21

0.31

2.90

-12.45

ENSG00000118113

MMP8

4.70

0.13

4.57

-12.43

ENSG00000103569

AQP9

1.59

-0.72

2.31

-12.41

ENSG00000140795

MYLK3

-0.78

1.87

-2.65

12.10

  1. These genes are most likely perturbed in CAU specifically due to HD and not due to brain region. Δ L2FC is the log2 fold change of (5) minus (3), where a positive value means that gene expression is greater in HD+ CAU vs BA9 than GTEx CAU vs BA9. Full results are in Additional file 5