Skip to main content

Table 9 Top 10 genes that show different effect sizes (L2FC) between (3) and (5)

From: The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

ENSGID Gene symbol HD+ L2FC (3) GTEx L2FC (5) Δ (3) vs (5) L2FC t
ENSG00000160401 CFAP157 -0.13 4.30 -4.43 20.45
ENSG00000077327 SPAG6 -2.20 2.64 -4.84 15.28
ENSG00000152611 CAPSL -2.59 3.65 -6.24 14.63
ENSG00000181085 MAPK15 -1.65 2.71 -4.36 12.89
ENSG00000154914 USP43 -3.32 -0.80 -2.52 12.87
ENSG00000169436 COL22A1 -3.82 -0.31 -3.51 12.82
ENSG00000259024 TVP23C-CDRT4 2.55 -0.02 2.57 -12.75
ENSG00000162747 FCGR3B 3.21 0.31 2.90 -12.45
ENSG00000118113 MMP8 4.70 0.13 4.57 -12.43
ENSG00000103569 AQP9 1.59 -0.72 2.31 -12.41
ENSG00000140795 MYLK3 -0.78 1.87 -2.65 12.10
  1. These genes are most likely perturbed in CAU specifically due to HD and not due to brain region. Δ L2FC is the log2 fold change of (5) minus (3), where a positive value means that gene expression is greater in HD+ CAU vs BA9 than GTEx CAU vs BA9. Full results are in Additional file 5