Fig. 2

Powers of different approaches on three two-locus disease models (Models 1–3) with 100 SNPs. Powers of DCHE, DECMDR, EDCF, HiSSI and HiSSI-BC on three two-locus disease models with different minor allele frequency (MAF), sample size (N) and linkage disequilibrium (LD); HiSSI-BC is a variant of HiSSI that uses the Bonferroni correction to obtain the corrected significant threshold. N0 is the number of controls, N1 is the number of cases, and M is the number of SNPs. The absence of a bar indicates no power. (a) Model1; (b) Model2; (c) Model3