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Table 2 Significant two-locus and three-locus combinations identified by HiSSI on WTCCC BC data

From: HiSSI: high-order SNP-SNP interactions detection based on efficient significant pattern and differential evolution

Significant InteractionChromosome and Related GenesSingle-Locusp-ValueInteractionp-Value
(rs1108842, rs2289247)(chr3: GNL3, chr3: GNL3)(1.139×10−2,5.981×10−1)6.048×10−45
(rs1130643, rs10017772)(chr4: SPARCL1, chr4: DCHS2)(2.823×10−1,3.830×10−1)2.865×10−8
(rs3761967, rs715748)(chr5: BDP1, chr5: BDP1)(1.720×10−1,4.073×10−1)1.238×10−54
(rs2242665, rs2856705)(chr6: SLC44A4, chr6: *)(3.484×10−4,6.178×10−8)4.369×10−25
(rs1801197, rs6971091)(chr7: CALCR, chr7: FAM71F1)(4.983×10−2,6.728×10−1)2.504×10−10
(rs365990, rs7158731)(chr14: MYH6, chr14: ZNF839)(8.807×10−3,3.319×10−3)1.636×10−6
(rs8059973, rs3785181)(chr16: DBNDD1, chr16: GAS11)(3.019×10−4,1.464×10−3)4.050×10−7
(rs2822558, rs2822787)(chr21: ABCC13, chr21: SAMSN1-AS1)(6.630×10−3,1.662×10−1)4.207×10−21
(rs879882, rs2523608, rs805262)(chr6: POU5F1, chr6: HLA-B, chr6: BAG6)(2.711×10−1,7.096×10−1,5.836×10−4)1.030×10−11
  1. *Indicates that the related gene is unknown.