Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans

Table 2 Regression results for the association between epigenetic age acceleration and target organ damage measures among GENOA African Americans

Target organ damage	Epigenetic age acceleration	Model 1		Model 2		Model 3
Target organ damage	Epigenetic age acceleration	β	P	β	P	β	P
eGFR (n = 1389)	IEAA	−0.082	0.444	−0.042	0.694	−0.035	0.745
eGFR (n = 1389)	EEAA	0.119	0.180	0.095	0.284	0.089	0.320
UACR^a (n = 1390)	IEAA	0.023	0.004	0.017	0.036	8.9E−3	0.246
UACR^a (n = 1390)	EEAA	0.010	0.187	7.2E-3	0.287	1.5E-3	0.826
RWT (n = 1352)	IEAA	6.2E−4	0.022	5.4E-4	0.041	4.5E-4	0.089
RWT (n = 1352)	EEAA	-3.4E-5	0.886	-4.8E-5	0.836	−1.2E-4	0.598
LVMI (n = 1346)	IEAA	0.163	0.007	0.110	0.054	0.062	0.260
LVMI (n = 1346)	EEAA	0.131	0.005	0.119	0.009	0.093	0.029
ABI (n = 1359)	IEAA	−2.1E-3	0.014	−1.9E-3	0.028	−1.6E-3	0.057
ABI (n = 1359)	EEAA	−1.2E-3	0.075	−1.0E-3	0.117	−8.4E−4	0.196
WMH^a (n = 758)	IEAA	-4.2e-3	0.333	−5.4e-3	0.213	−7.8e-3	0.075
WMH^a (n = 758)	EEAA	6.8e-3	0.068	7.0e-3	0.053	5.7e-3	0.109

Abbreviations: IEAA Intrinsic epigenetic age acceleration, EEAA Extrinsic epigenetic age acceleration, eGFR Estimated glomerular filtration rate, UACR Urinary albumin to creatinine ratio, RWT Relative wall thickness, LVMI Left ventricular mass index, ABI Ankle-brachial index, WMH White matter hyperintensity
Model 1: Target organ damage = epigenetic age acceleration + chronological age + sex + time between methylation and target organ damage measure
Model 2: Target organ damage = Model 1 covariates + SBP + DBP + antihypertensive medication
Model 3: Target organ damage = Model 2 covariates + smoking + diabetes + BMI
Model 3 for RWT and LVM also includes microalbuminuria and macroalbuminuria
All models for WMH also include total intracranial volume (TIV)
^aVariables were natural log transformed prior to analysis
Bold values correspond to beta values and p-values, where p < 0.05

ISSN: 1755-8794