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Table 2 Regression results for the association between epigenetic age acceleration and target organ damage measures among GENOA African Americans

From: Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans

Target organ damage Epigenetic age acceleration Model 1 Model 2 Model 3
β P β P β P
eGFR (n = 1389) IEAA −0.082 0.444 −0.042 0.694 −0.035 0.745
EEAA 0.119 0.180 0.095 0.284 0.089 0.320
UACRa (n = 1390) IEAA 0.023 0.004 0.017 0.036 8.9E−3 0.246
EEAA 0.010 0.187 7.2E-3 0.287 1.5E-3 0.826
RWT (n = 1352) IEAA 6.2E−4 0.022 5.4E-4 0.041 4.5E-4 0.089
EEAA -3.4E-5 0.886 -4.8E-5 0.836 −1.2E-4 0.598
LVMI (n = 1346) IEAA 0.163 0.007 0.110 0.054 0.062 0.260
EEAA 0.131 0.005 0.119 0.009 0.093 0.029
ABI (n = 1359) IEAA −2.1E-3 0.014 −1.9E-3 0.028 −1.6E-3 0.057
EEAA −1.2E-3 0.075 −1.0E-3 0.117 −8.4E−4 0.196
WMHa (n = 758) IEAA -4.2e-3 0.333 −5.4e-3 0.213 −7.8e-3 0.075
EEAA 6.8e-3 0.068 7.0e-3 0.053 5.7e-3 0.109
  1. Abbreviations: IEAA Intrinsic epigenetic age acceleration, EEAA Extrinsic epigenetic age acceleration, eGFR Estimated glomerular filtration rate, UACR Urinary albumin to creatinine ratio, RWT Relative wall thickness, LVMI Left ventricular mass index, ABI Ankle-brachial index, WMH White matter hyperintensity
  2. Model 1: Target organ damage = epigenetic age acceleration + chronological age + sex + time between methylation and target organ damage measure
  3. Model 2: Target organ damage = Model 1 covariates + SBP + DBP + antihypertensive medication
  4. Model 3: Target organ damage = Model 2 covariates + smoking + diabetes + BMI
  5. Model 3 for RWT and LVM also includes microalbuminuria and macroalbuminuria
  6. All models for WMH also include total intracranial volume (TIV)
  7. aVariables were natural log transformed prior to analysis
  8. Bold values correspond to beta values and p-values, where p < 0.05