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Table 3 Phenotypic, genetic, and environmental correlations between epigenetic age acceleration and target organ damage measures among GENOA African Americans

From: Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans

Target organ damage Epigenetic age accleration Model h2 TOD h2 EAA ρP ρG ρE
UACRa IEAA 1 0.383*** 0.484*** 0.067* −0.075 0.176*
2 0.376*** 0.510*** 0.056* 0.066 0.050
RWT IEAA 1 0.265*** 0.483*** 0.060* 0.001 0.097
2 0.246*** 0.510*** 0.056* 0.086 0.042
LVMI IEAA 1 0.563*** 0.480*** 0.064* −0.032 0.168
EEAA 1 0.566*** 0.604*** 0.062* −0.056 0.229
2 0.506*** 0.601*** 0.066* −0.005 0.155
3 0.440*** 0.604*** 0.056* −0.022 0.144
ABI IEAA 1 0.354*** 0.483*** −0.074** −0.004 − 0.125
2 0.355*** 0.510*** −0.067* −0.037 − 0.092
  1. Abbreviations: IEAA Intrinsic epigenetic age acceleration, EEAA Extrinsic epigenetic age acceleration, UACR Urinary albumin to creatinine ratio, RWT Relative wall thickness, LVMI Left ventricular mass index, ABI Ankle-brachial index, h2 Heritability estimate, ρP Phenotypic correlation, ρG Genetic correlation, ρE = environmental correlation
  2. Model 1 covariates: chronological age + sex + time between methylation and target organ damage measure
  3. Model 2 covariates: Model 1 covariates + SBP + DBP + antihypertensive medication
  4. Model 3 covariates: Model 2 covariates + smoking + diabetes + BMI + albuminuria
  5. aVariables were natural log transformed prior to analysis
  6. p < 0.1, *p < 0.05, **p < 0.01, ***p < 0.001