Fig. 5
From: Detection of large rearrangements in a hereditary pan-cancer panel using next-generation sequencing
Laboratory evidence of a triplication found in BRCA2. a Next-generation sequencingNGS data showing a triplication of exons 14–24 of BRCA2. Exons at a normal dosage align to 2 alleles on the y-axis, whereas triplicated exons align to about four alleles. b Microarray-based comparative genomic hybridization data showing a triplication of exons 14–24. Microarray probe clusters at normal dosage center at zero on the y-axis, whereas triplications center at approximately 0.75–1.0