Fig. 4

The genetic landscape of the 27 discordant cases, comprising 9 fibroadenomas (FAs) and 18 phyllodes tumors (PTs). This figure demonstrates the discrepancies between the original pathological diagnoses of the FELs and the diagnoses of the fibroepithelial lesions based on the predictive scoring model and the 16-gene assay. Top, pathological diagnoses, the sample identification number and type of biopsy material. Samples that have their diagnoses changed on second pathology review are highlighted. Left, the 16 genes used in the targeted sequencing of these lesions are listed. The colored rectangles indicate the type of somatic mutations observed in the lesions through the 16-gene assay. Bottom, the respective predictive scores calculated based on the scorecard (Table 6) and their corresponding classifications by the 16-gene assay