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Fig. 5 | BMC Medical Genomics

Fig. 5

From: A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions

Fig. 5

Histological features of the discordant FELs which had their diagnoses changed on second review. a-c Samples 52 and 114 were FA samples upgraded to Benign PTs on review. (D-G) Samples 63 and 105 were PT samples which were downgraded to FAs. a Sample 52. Benign fibroepithelial tumor showed well-formed stromal fronds, favoring a benign phyllodes tumor. This was originally diagnosed as a fibroadenoma. b Sample 114. Low magnification view of the excised fibroepithelial tumor, with areas showing stromal fronds. c Sample 114. On higher magnification, the stromal fronds showed slightly increased cellularity, with peri-epithelial accentuation, in keeping with a benign phyllodes tumor. d Sample 63. Low magnification view showed a benign fibroepithelial tumor with areas of adenosis and cysts, accompanied by increased stromal cellularity which appeared diffuse. e Sample 63. Higher magnification affirmed the increased stromal cellularity which had a fascicular pattern, with the epithelial component observed as dilated ducts and crowded benign bilayered glands. Upon histological review, this case was regarded as more in keeping with a complex cellular fibroadenoma with cysts. f Sample 105. Low magnification view of a benign fibroepithelial tumor, with some clefts (left field) suggesting the presence of fronds. However, overall the tumor had hyalinized and slightly myxoid stroma without increased stromal cellularity. g Sample 105. Higher magnification showed the intracanalicular pattern of the tumor which was reviewed as favoring a fibroadenoma

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