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Table 2 Frequencies of mutations in the 16 genes, by FEL subtypes. Benign (BEN), borderline (BDR) and malignant (MAL) phyllodes tumor (PT)

From: A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions

Gene Fibroadenoma
(n = 167)
Phyllodes Tumor (n = 44) p value
BEN (n = 24) BDR (n = 14) MAL (n = 6) All PT
n (%) n (%) n (%) n (%) n (%)
MED12 75 (44.9) 16 (66.7) 9 (64.3) 2 (33.3) 27 (61.4) 0.063
TERT 6 (3.6) 11 (45.8) 8 (57.1) 2 (33.3) 21 (47.7) <  0.001
KMT2D 30 (18.0) 6 (25.0) 1 (7.1) 0 (0.0) 7 (15.9) 0.827
RARA 5 (3.0) 7 (29.2) 6 (42.9) 0 (0.0) 13 (29.6) <  0.001
SETD2 36 (21.6) 5 (20.8) 8 (57.1) 0 (0.0) 13 (29.6) 0.316
FLNA 16 (9.6) 8 (33.3) 3 (21.4) 2 (33.3) 13 (29.6) 0.002
NF1 7 (4.2) 1 (4.2) 0 (0.0) 1 (16.7) 2 (4.6) 1.000
EGFR 4 (2.4) 0 (0.0) 2 (14.3) 1 (16.7) 3 (6.8) 0.160
RB1 6 (3.6) 2 (8.3) 2 (14.3) 2 (33.3) 6 (13.6) 0.020
TP53 2 (1.2) 1 (4.2) 0 (0.0) 3 (50.0) 4 (9.1) 0.018
PIK3CA 4 (2.4) 1 (4.2) 1 (7.1) 0 (0.0) 2 (4.6) 0.607
BCOR 4 (2.4) 0 (0.0) 2 (14.3) 0 (0.0) 2 (4.6) 0.607
PTEN 0 (0.0) 0 (0.0) 1 (7.1) 0 (0.0) 1 (2.3) 0.209
ERBB4 2 (1.2) 1 (4.2) 0 (0.0) 0 (0.0) 1 (2.3) 0.506
MAP3K1 2 (1.2) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1.000
IGF1R 3 (1.8) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1.000