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Table 5 A summary of the univariate analyses performed to understand the effect of each potential predictor in the classification of the fibroepithelial lesions. Predictors (Ɨ), with p < 0.10, were included in the multivariate analysis

From: A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions

Predictors Odds Ratio (OR) 95% Confidence Interval (CI) p value
Genes
MED12Ɨ 1.95 0.99 to 3.84 0.054
TERT promoterƗ 24.50 8.95 to 67.07 < 0.001
KMT2D 1.10 0.46 to 2.60 0.836
RARAƗ 13.59 4.52 to 40.84 < 0.001
SETD2 1.53 0.72 to 3.22 0.266
FLNAƗ 3.96 1.73 to 9.06 0.001
NF1 1.09 0.22 to 5.43 0.918
EGFR 2.98 0.64 to 13.85 0.163
RB1Ɨ 4.24 1.29 to 13.86 0.017
TP53Ɨ 8.25 1.46 to 46.64 0.017
PIK3CA 1.94 0.34 to 10.96 0.453
BCOR 1.94 0.34 to 10.96 0.453
PTEN Excluded, frequency < 5
ERBB4 1.92 0.17 to 21.66 0.598
MAP3K1 Excluded, frequency < 5
IGF1R Excluded, frequency < 5
Mutation types
 Missense 1.76 0.81 to 3.82 0.152
 PromoterƗ 24.50 8.95 to 67.07 < 0.001
 Non Frameshift 1.19 0.54 to 2.67 0.664
 FrameshiftƗ 7.20 2.23 to 23.30 0.001
 NonsenseƗ 26.20 3.06 to 224.10 0.003
 Splice site Excluded, frequency < 5
Mutation count
 Mutation count (≥3) Ɨ 13.11 5.85 to 29.40 < 0.001