Skip to main content
Fig. 1 | BMC Medical Genomics

Fig. 1

From: Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium

Fig. 1

a UCSC Genome Browser screenshot of epigenetic landscape around SNP rs1800255 within the exon of COL3A1. Black horizontal bar at top represents the LD block of the associated IA-risk SNP. The next tracks in descending order within panel A are the H3K4me1 and H3K27ac peak regions generated from ChIP-Seq data for monocytes (CD14+), PBMCs, and HUVECs. Gray bars in the lower section represent transcription factor ChIP-Seq of 8 factors from ENCODE with data available for HUVECs. Notice that COL3A1 is expressed in this LD block. Histone marked regions, represented by the gray bars in the middle of this panel, are only present for HUVECs and encompass multiple TFBSs. b Tracks for neutrophil H3K4me1 and H3K27ac peak regions generated from ChIP-Seq data. Key: UCSC=University of California Santa Cruz, SNP = single nucleotide polymorphism, COL3A1 = collagen type III alpha chain a, LD = linkage disequilibrium, IA = intracranial aneurysm, PBMC = peripheral blood mononuclear cell, HUVEC = human umbilical vein endothelial cell, ChIP-Seq = chromatin immunoprecipitation-sequencing, TFBS = transcription factor binding site; ENCODE = Encyclopedia of DNA [deoxyribonucleic acid] Elements

Back to article page