Fig. 2

a UCSC Genome Browser screenshot of epigenetic landscape around intergenic SNP rs10958409. Black horizontal bar at the top represents the LD block of the associated IA-risk SNP. The next tracks are for monocyte (CD14+), PBMC, and HUVEC H3K4me1 and H3K27ac peak regions generated from ChIP-Seq data. Gray bars in the lower section of panel A represent transcription factor ChIP-Seq of 8 factors from ENCODE with data available for HUVECs. Histone marked regions, represented by the gray bars in the middle of panel A, are only present for HUVECs and encompass multiple TFBS. b Tracks for neutrophil H3K4me1 and H3K27ac peak regions generated from ChIP-Seq data. Key: UCSC=University of California Santa Cruz, SNP = single nucleotide polymorphism, LD = linkage disequilibrium, IA = intracranial aneurysm, PBMC = peripheral blood mononuclear cell, HUVEC = human umbilical vein endothelial cell, ChIP-Seq = chromatin immunoprecipitation-sequencing, TFBS = transcription factor binding site). ENCODE = Encyclopedia of DNA [deoxyribonucleic acid] Elements