Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium

BMC Medical Genomics

Table 1 Positional information for 16 IA-risk single nucleotide polymorphisms and the associated linkage disequilibrium blocks^a

SNP	LD Block	SNP Location	Nearest Gene in LD Block
rs4934	chr14:95078677–95,080,803	Exonic	SERPINA3
rs42524	chr7:94043239–94,049,356	Exonic	COL1A2
rs1132274	chr20:17594030–17,600,114	Exonic	RRBP1
rs1800255	chr2:189841613–189,867,882	Exonic	COL3A1
rs1429412	chr2:198148191–198,223,121	Intergenic	ANKRD44
rs6841581	chr4:148365339–148,414,651	Intergenic	EDNRA
rs9298506	chr8:55421614–55,462,324	Intergenic	–
rs10757278	chr9:22077085–22,125,503	Intergenic	CDKN2B-AS1
rs10958409	chr8:55309731–55,328,116	Intergenic	–
rs251124	chr5:82805424–82,826,254	Intronic	VCAN
rs700651	chr2:198541398–198,631,714	Intronic	BOLL
rs1800796	chr7:22766246–22,771,738	Intronic	IL6
rs2891168	chr9:22072264–22,125,503	Intronic	CDKN2B-AS1
rs3767137	chr1:22160723–22,168,310	Intronic	HSPG2
rs4628172	chr7:15493884–15,506,529	Intronic	AGMO
rs6538595	chr12:95489131–95,516,843	Intronic	FGD6

^aSNPs reported by Alg et al. [25] were mapped to LD blocks using SNAP and SNiPA tools. The UCSC Genome Browser was used to visually determine SNP location and nearest gene
Abbreviations: chr Chromosome, LD Linkage disequilibrium, rs Reference SNP cluster ID, SNP Single nucleotide polymorphism, “–” = no gene)

ISSN: 1755-8794