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Table 4 TF binding sites present within histone-marked regions of IA-associated LD blocks for endothelial cellsa

From: Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium

LD Block

SNP

Distal TF

Promoter TF

chr1:22160723–22,168,310

rs3767137

POLR2A

chr2:189841613–189,867,882

rs1800255

FOS, GATA2, JUN

chr2:198148191–198,223,121

rs1429412

FOS, GATA2, JUN

chr2:198541398–198,631,714

rs700651

FOS

MAXb, MYCb, POLR2Ab

chr4:148365339–148,414,651

rs6841581

EZH2

chr5:82805424–82,826,254

rs251124

JUNb

chr7:15493884–15,506,529

rs4628172

FOS

chr7:22766246–22,771,738

rs1800796

FOSb, GATA2b, JUNb, POLR2Ab

POLR2Ab

chr7:94043239–94,049,356

rs42524

FOS, JUN

chr8:55309731–55,328,116

rs10958409

FOS, GATA2, JUN

chr8:55421614–55,462,324

rs9298506

chr9:22072264–22,125,503

rs2891168

FOSb, GATA2b, JUNb, POLR2Ab

chr9:22077085–22,125,503

rs10757278

FOSb, GATA2b, JUNb, POLR2Ab

chr12:95489131–95,516,843

rs6538595

FOSb, GATA2b, JUNb, POLR2Ab

chr14:95078677–95,080,803

rs4934

chr20:17594030–17,600,114

rs1132274

  1. a TF binding site identification only performed for HUVEC. All TFs were present within H3K4me1-marked regions of IA-associated LD blocks. TFs denoted with b were present in regions of IA-associated LD blocks marked by both H3K4me1 and H3K27ac histone modifications. (IA Intracranial aneurysm, LD Linkage disequilibrium, chr Chromosome, SNP Single nucleotide polymorphism, HUVEC Human umbilical vein endothelial cell, “–” = no TF)