Table 2 Predicted (approach 2) and determined (Suter et al. [38]) binding preferences of ATXN1 partners with the wt and expanded ATXN1. In bold are those proteins for which the prediction is different when using the two in-silico methodologies
From: ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms
This work | Suter et al. | Proteins names (GeneID; UniProtKB) |
|---|---|---|
wt | wt | CXorf27 (25763; O75409); GGA2 (23062; Q9UJY4); TOMM20 (9804; Q15388) |
expanded | expanded | BAALC (79870; Q8WXS3); BASP1 (10409; P80723); C16orf5 (29965; Q9H305); C2orf27B (408029; Q580R0); CREM (1390; Q03060); CRIP2 (1397; P52943); CRK (1398; P46108); DHRSX (207063; Q8N5I4); ESRRA (2101; P11474); FAM46A (55603; Q96IP4); FAM46B (115572; Q96A09); FAR1 (84188; Q8WVX9); GATAD1 (57798; Q8WUU5); HEY2 (23493; Q9UBP5); HNRPLL (92906; Q8WVV9); IMMT (10989; Q16891); KCTD15 (79047; Q96SI1); KIF22 (3835; Q14807); LPAR2 (9170; Q9HBW0); MCART1 (92014; Q9H1U9); MSX2 (4488 (P35548); NCAM1 (4684; P13591); OTX2 (5015; P32243); PIAS1 (8554; O75925); PLEKHB1 (58473; Q9UF11); PPAT (5471; Q06203); PSPH (5723; P78330); QKI (9444; Q96PU8); RAPGEF1 (2889; Q13905); RBM9 (23543; O43251); SF1 (7536; Q15637); SLC6A13 (6540; Q9NSD5); SV2A (9900; Q7L0J3); TMX2 (51075; Q9Y320); TRIM38 (10475; O00635); TTRAP (51567; O95551); UHRF2 (115426; Q96PU4); YWHAE (7531 (P62258); ZC3H10 (84872; Q96K80); ZSCAN1 (284312; Q8NBB4) |
wt | expanded | CRY2 (1408; Q49AN0); EIF1B (10289; O60739); LITAF (9516; Q99732); RAI2 (10742; Q9Y5P3); RBM26 (64062; Q5T8P6); SEMA4G (57715; Q9NTN9); TCTA (6988; P57738); TP53I11 (9537; O14683) |
expanded | wt | ADD3 (120; Q9UEY8); ASNS (440; P08243); CAMK2B (816; Q13554); DHX37 (57647; Q8IY37); DIXDC1 (85458; Q155Q3); EIF3F (8665; O00303); ETV4 (2118; P43268); HEYL (26508; Q9NQ87); ILVBL (10994; A1L0T0); MAGEB18 (286514; Q96M61); MAGEB2 (4113; O15479); MAGEB6 (158809; Q8N7X4); WBSCR16 (81554; Q96I51) |
expanded | no preference | ARID5A (10865; Q03989); CHRNA7 (1139; P36544); FOSL1 (8061; P15407); LASP1 (3927; Q14847); MLST8 (64223; Q9BVC4); STAM2 (10254; O75886); TSC1 (7248; Q92574) |